Interferon-α and somatostatin analog in patients with gastroenteropancreatic neuroendocrine carcinoma: single agent or combination?
نویسندگان
چکیده
منابع مشابه
Should interferon-α and somatostatin analogs be combined in gastroenteropancreatic neuroendocrine tumor therapy?
10.2217/14750708.2.2.229 © 2 part of Gastroenteropancreatic are the most common of the neuroendocrine tumors. They are usually well differentiated and slow growing, and express subtype 2 and 5 somatostatin receptors in most cases. Both somatostatin anologs and interferon-α were used as single agent, showing symptomatic, biochemical, and in a minority of cases, even antiproliferative activity. I...
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BACKGROUND AND AIM To investigate the efficacy of platinum-based chemotherapy in patients with metastatic gastroenteropancreatic neuroendocrine carcinoma (mGEP-NEC) and define predictive and prognostic factors. METHODS Twenty mGEP-NEC patients were treated with cisplatin or carboplatin/etoposide between April 2010 and October 2014. Both large-cell and small-cell histologies were included. Cis...
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Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of malignancies, characterized by varying degrees of biological activity and metastatic potential. A common thread between this wide mix of neoplasms has remained their sensitivity to hormonal modulation with somatostatin analogues. New analogues of somatostatin have been recently introduced and are beginning to shape a diff...
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Objective. Patients with gastroenteropancreatic neuroendocrine carcinoma (NEC) have a poor prognosis. Platinum-based combination chemotherapy is commonly used as first-line treatment; however, the role of salvage chemotherapy remains unknown. This study aimed to analyze the efficacy and safety of amrubicin monotherapy in patients with platinum-refractory gastroenteropancreatic NEC. Methods. Amo...
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Somatostatin receptor imaging (SRI) with [(111)In-DTPA(0)]octreotide has proven its role in the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEPNETs). Newer radiolabeled somatostatin analogs which can be used in positron emission tomography (PET) imaging, and which have a higher affinity for the somatostatin receptor, especially receptor subtype-2, have been developed....
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2007
ISSN: 0923-7534
DOI: 10.1093/annonc/mdl144